The rate of meiotic gene conversion varies by sex and age

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rate of meiotic gene conversion varies by sex and ageAU – Halldorsson, Bjarni V .

AU – Hardarson, Marteinn T .AU – Kehr, BirteAU – Styrkarsdottir, UnnurAU – Gylfason, ArnaldurAU – Thorleifsson, GudmarAU – Zink, FlorianAU – Jonasdottir, AdalbjorgAU – Jonasdottir, AslaugAU – Sulem, PatrickAU – Masson, GisliAU – Thorsteinsdottir, UnnurAU – Helgason, AgnarAU – Kong, AugustineAU – Gudbjartsson, Daniel F .AU – Stefansson, KariN1 – quảng cáo online Copyright : © năm nay Nature America, Inc., part of Springer Nature. All rights reserved .PY – 2016/11/1Y1 – 2016/11/1N2 – Meiotic recombination involves a combination of gene conversion and crossover events that, along with mutations, produce germline genetic diversity. Here we báo cáo the discovery of 3,176 SNP and 61 indel gene conversions. Our estimate of the non-crossover ( NCO ) gene conversion rate ( G ) is 7.0 for SNPs and 5.8 for indels per megabase per generation, and the GC bias is 67.6 %. For indels, we demonstrate a 65.6 % preference for the shorter allele. NCO gene conversions from mothers are longer than those from fathers, and G is 2.17 times greater in mothers. Notably, G increases with the age of mothers, but not the age of fathers. A disproportionate number of NCO gene conversions in older mothers occur outside double-strand break ( DSB ) regions and in regions with relatively low GC nội dung. This points lớn age-related changes in the mechanisms of meiotic gene conversion in oocytes .AB – Meiotic recombination involves a combination of gene conversion and crossover events that, along with mutations, produce germline genetic diversity. Here we báo cáo the discovery of 3,176 SNP and 61 indel gene conversions. Our estimate of the non-crossover ( NCO ) gene conversion rate ( G ) is 7.0 for SNPs and 5.8 for indels per megabase per generation, and the GC bias is 67.6 %. For indels, we demonstrate a 65.6 % preference for the shorter allele. NCO gene conversions from mothers are longer than those from fathers, and G is 2.17 times greater in mothers. Notably, G increases with the age of mothers, but not the age of fathers. A disproportionate number of NCO gene conversions in older mothers occur outside double-strand break ( DSB ) regions and in regions with relatively low GC nội dung. This points phệ age-related changes in the mechanisms of meiotic gene conversion in oocytes .UR – http://www.scopus.com/inward/record.url?scp=84988353525&partnerID=8YFLogxKU2 – 10.1038 / ng. 3669DO – 10.1038 / ng. 3669M3 – ArticleC2 – 27643539AN – SCOPUS : 84988353525SN – 1061 – 4036VL – 48SP – 1377EP – 1384JO – Nature GeneticsJF – Nature GeneticsIS – 11

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